A brief prodrome resembling a “viral-like”
illness, characterized by myalgia, fatigue, fever, with or without
respiratory symptoms, followed by hypoxia and dyspnea, often with
radiographic evidence of mediastinal widening.
Many LRN laboratories use rapid screening
assays (PCR for nucleic acid amplification and TRF immunoassay for antigen
detection) on cultures and directly on clinical specimens.
confirmatory criteria for identification of B. anthracis is
Capsule production and visualization and lysis
by gamma-phage or
Direct fluorescent antibody assays (DFA) for
capsule antigen and cell wall-associated polysaccharide